Gladson: Pharmacology for Rehabilitation Professionals, 2nd Edition

Chapter 01: Introduction

Test Bank

MULTIPLE CHOICE 

1) The effectiveness of a drug in large populations is the subject of __________.

A. pharmacogenomics
B. pharmacodynamics
C. pharmacoepidemiology
D. pharmacokinetics

ANS: C 
Pharmacogenomics studies the genetic basis of drug responses. Pharmacodynamics studies drug- receptor interactions. Pharmacokinetics studies the fate of a drug in the body. 

2) Rehabilitative therapists should know pharmacology because __________.

A. drugs can cause effects which interfere with physical therapy
B. proper drug administration scheduling can help physical therapy
C. certain therapies like hot baths can seriously interact with certain drugs
D. All of the above

ANS: D 

3) Approval for marketing of a drug is done by the __________.

A. Food and Drug Administration
B. U.S. Health Department
C. American Medical Association
D. National Institute of Health

ANS: A 
The U.S. Health Department, American Medical Association, and National Institute of Health might advise but do not approve.

4) Before a drug is approved, the company must submit data verifying that the drug __________.

A. is efficacious
B. has acceptable toxicity
C. should be marketed at a particular dose and indication
D. All of the above

ANS: D 

5) Clinical trials of a new drug are divided into 4 phases. Which description is correct?

A. Phase I tests the drug in only 20 patients who are mildly ill. 
B. Phase II tests the drug in about 40-50 patients who are seriously ill.
C. Phase III tests the drug in about 3000-10,000 patients.
D. Phase IV re-tests the drug in about 500 patients who were previously drug non-responders.

ANS: C 
Phase I uses healthy volunteers. Phase II tests about 100-200 patients. Phase IV begins when the drug is approved for public use. No phase deals with drug non-responders.

6) To bring a new drug on the market takes about __________.

A. 1 year
B. 5 years 
C. 8 years
D. 12 years

ANS: D 
It takes about 12 years including 3-4 years for preclinical studies and about 8-9 years for Phase I-III studies at a cost of about $800 to 100 million.

7) A prescription must contain all of the following information except __________.

A. physician’s name, credentials, address, telephone number, and signature
B. the drug name, dose and how the drug is to be administered
C. the patient’s full name and address
D. the name of the pharmacy that is supposed to fill the prescription

ANS: D 
The pharmacy can be selected by the patient but all the other information must be provided.

8) Controlled substances are divided into schedules. Which of the following schedule descriptions is false?

A. Schedule I: Substances used for research only with no clinical use.
B. Schedule II: Drugs with a high potential for physical and psychological abuse but limited medical use with no refills. 
C. Schedule III: Drugs with moderate potential for abuse and wider therapeutic use but refills allowed.
D. Schedule IV: Drugs with no potential for abuse and wide therapeutic use and unlimited refills allowed.

ANS: D 
Drugs with mild to moderate potential for abuse are included in schedule IV.

9) Morphine, fentanyl and oxycodone are in schedule __________.

A. I
B. II
C. III
D. IV

ANS: B 
Only opioids, which are formulated with aspirin or acetaminophen, fall in schedule III. 

10) The year it was required that marketed drugs be shown by the pharmaceutical company to be both efficacious and relatively safe is __________.

A. 1855
B. 1909
C. 1934
D. 1962

ANS: D 
The Kefauver-Harris Amendments to the Food, Drug, and Cosmetic Act required evidence of both efficacy and relative safety and were signed in 1962. 

11) The abbreviation prn stands for __________.

A. as needed
B. every day
C. before meals
D. twice a day

ANS: A 
Every day is ad, before meals is ac, and twice a day is bid.

12) The official medical name of a drug is the __________.

A. chemical name
B. brand name
C. proprietary name
D. generic name

ANS: D 
All the other names are secondary names important for research and/or marketing.

13) Which of the following statements is true?

A. A drug can have many brand names. 
B. A drug can have many chemical names.
C. A drug can have many generic names.
D. The generic name of a drug must be changed after a patent has been expired.

ANS: A 
A drug has only one chemical and one generic name but can be marketed under many different brand names. While the brand name might be retired after a patent has expired, the chemical and generic names will always stay with the drug as long as it is being marketed. 

14) Drugs can be classified and grouped pharmacologically and therapeutically according to their __________.

A. chemical structures
B. source or origin
C. mode of action
D. All of the above

ANS: D 
Drugs can be classified and grouped according to their chemical structure (e.g., benzodiazepines), their source of origin (e.g., antibiotics from microorganisms) and mode of action (e.g., beta receptor blockers).